太阳电池I－V数据采集系统

本文利用ＩＥＥＥ－４８８接口板，Ｋｅｉｔｈｌｅｙ６１７静电计，ＩＢＭ－ＰＣ微机，编程实现了太阳电池Ｉ－Ｖ数据的自动采集、存储．以ａ－Ｓｉ：ＨＰｉｎ型太阳电池为样品，计算出相应的电池参量，验证了该系统的可行性和准确性．     

矿区铁路专用线下综采放顶煤开采的试验研究

介绍了国内第一个综采放顶煤开采矿区铁路线下压煤试验面的成功经验，总结了试采中对铁路所采取的各种分析和维护措施，分析了该采煤方法下的地在移动和变形特点，为我国“三下”采煤领域提供了具有特色的成功实例。     

约束条件下直动凸轮机构最佳偏距的程序优化

在直动从动件盘形凸轮的设计中，减少推程压力角可改善凸轮的受力条件，适当的偏置可以减少压力角。本文通过计算机设计方法来确定具有最小凸轮机构尺寸时的最佳偏距。     

钢-混凝土连续组合梁桥的理论分析和试验研究

根据完全剪力连接的连续组合梁桥的构造特点及各部分受力机理,做出合理假设,提出分层平面框架计算模型该计算模型用于沈阳市东西快速干道工程某段连续组合梁桥,计算值与静载试验实测值非常接近,证明了本计算模型用于钢-混凝土连续组合梁桥正确实用的.     

Functional magnetic resonance imaging of amphetamine craving

The aim of this study is to identify the brain activity associated with amphetamine craving for understanding the neurobiology of addiction by watching pictures of happy, sad or amphetamine. Brain activity was measured in 12 amphetamine addicts and 12 healthy subjects by fMRI while the subjects watched pictures designed to elicit happy feelings, sad feelings, or the desire to use amphetamine. The result demonstrated that amphetamine cues led to abnormally high cingulate and low frontal lobe activation in amphetamine addicts, who showed abnormalities in affect-related brain activation.     

背诵——基于模因论的英语输入策略

阐述了当前大学英语教学中语言输入不足之现状,提出了以模因论为理论基础的背诵输入策略,指出将背诵输入策略运用于英语教学的重大意义。     

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid beta peptide (Abeta) in Alzheimer disease. We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease. These variants, which occur in at least two different clusters of intronic sequences within the SORL1 gene (also known as LR11 or SORLA) may regulate tissue-specific expression of SORL1. We also show that SORL1 directs trafficking of APP into recycling pathways and that when SORL1 is underexpressed, APP is sorted into Abeta-generating compartments. These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease.     

Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer

During its lifetime, the mammary gland undergoes many phases of development and differentiation. Much of this occurs during puberty, when the ductal epithelium expands by branching morphogenesis, invading the surrounding fat pad to form an organised mammary tree. Throughout its existence, the epithelium will go through several cycles of proliferation and cell death during pregnancy, lactation and involution. Many of the signalling mechanisms which control the initial invasion of the fat pad by the epithelium, and regulate its continuing plasticity, can be harnessed or corrupted by tumour cells in order to support their aberrant growth and progression towards invasion. This is true not just for the epithelial cells themselves but also for cells in the surrounding microenvironment, including fibroblasts, macrophages and adipocytes. This review examines the complex web of signalling and adhesion interactions controlling branching morphogenesis, and how their alteration can promote malignancy. Current in vivo and in vitro mammary gland models are also discussed. (Part of a Multi-author Review)